48 research outputs found
Two-dimensional lattice Boltzmann simulations of vesicles with viscosity contrast
We present a numerical approach to simulate the dynamics of viscous vesicles (their internal and external fluids have different viscosities). The flow is computed using the lattice Boltzmann method and the fluid-vesicle two-way coupling is achieved using the immersed boundary method. The viscosity contrast (defined as the ratio of the internal to the external viscosities) is included using a geometrical algorithm that detects if a fluid node is either located inside or outside a vesicle. Our two-dimensional simulations successfully reproduce the tank-treading and tumbling dynamical states known for a viscous vesicle when it is subjected to simple shear flow. A good qualitative agreement between our simulation results and literature data is obtained. Moreover, we quantitatively analyze how inertia influences the dynamics of a vesicle and as an outlook we present an application of our method to the flow of multiple viscous vesicles in a microfluidic constriction
Computer simulations of shape deformation and dynamics of biological cells subjected to flow
Sheet presentati
Study Of Inertia And Stoichiometric Effect On Surface Diffusion By Monte Carlo Method
In this work, we investigate the inertia and stoichiometric effect on surface diffusion of adsorbates particles. The study is done by means of Monte-Carlo simulation in the framework of the lattice gas model. Only first neighboring repulsive pair interaction is considered. We concentrate on the behaviour of the tracer diffusion coefficient Dt(θ), as a function of surface coverage θ in the case where two type of particles A and B are adsorbed. A and B are only different by their mass. The results shows that θt ordering phenomenon is not strongly influenced. However the diffusion process is decreased by inclusion of heavy particles.w.In this work, we investigate the inertia and stoichiometric effect on surface diffusion of adsorbates particles. The study is done by means of Monte-Carlo simulation in the framework of the lattice gas model. Only first neighboring repulsive pair interaction is considered. We concentrate on the behaviour of the tracer diffusion coefficient Dt(θ), as a function of surface coverage θ in the case where two type of particles A and B are adsorbed. A and B are only different by their mass. The results shows that θt ordering phenomenon is not strongly influenced. However the diffusion process is decreased by inclusion of heavy particles.w
Phase-field modelling of dendritic growth behaviour towards the cooling / heating of pure nickel
We are interested in modelling the dendritic growth occurring during the solidification process of a pure material and especially to see the effect of the cooling / heating on the growth behaviour of this dendrite. For this purpose we use a phase-field model. The obtained partial differential equations are solved numerically by a finite difference method. In order to appreciate the shape of the resulting dendrites we expose some figures obtained from simulations in 2D.We are interested in modelling the dendritic growth occurring during the solidification process of a pure material and especially to see the effect of the cooling / heating on the growth behaviour of this dendrite. For this purpose we use a phase-field model. The obtained partial differential equations are solved numerically by a finite difference method. In order to appreciate the shape of the resulting dendrites we expose some figures obtained from simulations in 2D
Lateral migration of a 2D vesicle in unbounded Poiseuille flow
The migration of a suspended vesicle in an unbounded Poiseuille flow is
investigated numerically in the low Reynolds number limit. We consider the
situation without viscosity contrast between the interior of the vesicle and
the exterior. Using the boundary integral method we solve the corresponding
hydrodynamic flow equations and track explicitly the vesicle dynamics in two
dimensions. We find that the interplay between the nonlinear character of the
Poiseuille flow and the vesicle deformation causes a cross-streamline migration
of vesicles towards the center of the Poiseuille flow. This is in a marked
contrast with a result [L.G. Leal, Ann. Rev. Fluid Mech. 12,
435(1980)]according to which the droplet moves away from the center (provided
there is no viscosity contrast between the internal and the external fluids).
The migration velocity is found to increase with the local capillary number
(defined by the time scale of the vesicle relaxation towards its equilibrium
shape times the local shear rate), but reaches a plateau above a certain value
of the capillary number. This plateau value increases with the curvature of the
parabolic flow profile. We present scaling laws for the migration velocity.Comment: 11 pages with 4 figure
Dumbbell transport and deflection in a spatially periodic potential
We present theoretical results on the deterministic and stochastic motion of
a dumbbell carried by a uniform flow through a three-dimensional spatially
periodic potential. Depending on parameters like the flow velocity, there are
two different kinds of movement: transport along a potential valley and
stair-like motion oblique to the potential trenches. The crossover between
these two regimes, as well as the deflection angle, depends on the size of the
dumbbell. Moreover, thermal fluctuations cause a resonance-like variation in
the deflection angle as a function of the dumbbell extension.Comment: 5 pages, 8 figure
Structuring with anisotropic colloids
Structure is an important factor in food. One of the ways to provide structure to foods is by using bubbles and foams. However, they need to be stabilized. One way of doing this is by covering them with microscopic rods. These rods self-assemble at the surface, yielding a stable bubble. The goal of this work is to gain a better understanding into how this self-assembly works using analytical calculations, experiments and simulations
Numerical simulations of complex fluid-fluid interface dynamics
Interfaces between two fluids are ubiquitous and of special importance for
industrial applications, e.g., stabilisation of emulsions. The dynamics of
fluid-fluid interfaces is difficult to study because these interfaces are
usually deformable and their shapes are not known a priori. Since experiments
do not provide access to all observables of interest, computer simulations pose
attractive alternatives to gain insight into the physics of interfaces. In the
present article, we restrict ourselves to systems with dimensions comparable to
the lateral interface extensions. We provide a critical discussion of three
numerical schemes coupled to the lattice Boltzmann method as a solver for the
hydrodynamics of the problem: (a) the immersed boundary method for the
simulation of vesicles and capsules, the Shan-Chen pseudopotential approach for
multi-component fluids in combination with (b) an additional
advection-diffusion component for surfactant modelling and (c) a molecular
dynamics algorithm for the simulation of nanoparticles acting as emulsifiers.Comment: 24 pages, 12 figure
Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study
Background Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours.Methods In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186.Findings Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78 center dot 6%] female patients and 4922 [21 center dot 4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1 center dot 4 [IQR 0 center dot 6-3 center dot 4]) compared with the prepandemic phase (2 center dot 0 [0 center dot 9-3 center dot 7]; p<0 center dot 0001) and pandemic decrease phase (2 center dot 3 [1 center dot 0-5 center dot 0]; p<0 center dot 0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69 center dot 0%] of 3704 vs 1515 [71 center dot 5%] of 2119; OR 1 center dot 1 [95% CI 1 center dot 0-1 center dot 3]; p=0 center dot 042), lymph node metastases (343 [9 center dot 3%] vs 264 [12 center dot 5%]; OR 1 center dot 4 [1 center dot 2-1 center dot 7]; p=0 center dot 0001), and tumours at high risk of structural disease recurrence (203 [5 center dot 7%] of 3584 vs 155 [7 center dot 7%] of 2006; OR 1 center dot 4 [1 center dot 1-1 center dot 7]; p=0 center dot 0039).Interpretation Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation.Funding None.Copyright (c) 2023 Published by Elsevier Ltd. All rights reserved